PPIP5K2 and keratoconus: Interestingly, heterozygous Ppip5k2+/K^ mice (Fig. 8) showed localized corneal thinning patterns resembling KC-associated clinical phenotype while homozygous Ppip5k2K^/K^ mice had a more progressed diffuse pattern of corneal thinning resembling that of keratoglobus-related phenotype.