In the pathophysiological process of sepsis, on the one hand, endotoxin directly damages the body, on the other hand, endotoxin induces a series of serious cascade inflammatory reactions, and produces a large number of early and late inflammatory factors such as TNF-α, IL-1β, etc. Inflammatory factors aggravate the cascade inflammatory reactions until induced septic shock, single organ or even multiple organ failure syndrome (MODS)36. Here, TNF is linked to Sepsis.