When compared to normal liver hepatocyte stem-like cells and normal skin fibroblasts, CHIP assay demonstrates the dysregulation of TP73 expression in HCC cells and GI cancer cells by TP53 and CTCF, possibly due to hypermethylation of TP73 promoter region (−1479 to −1226). This evidence concerns the gene CTCF and hepatocellular carcinoma.