The genes that are proximal to TP73 (i.e. PRDM16, MEGF6, CEP104 and DFFB) in the region of chromosome 1 p36.32 (Fig. 2A), were assessed for their expression in human normal liver stem cells (HepCY and HepCO), hepatocellular cancer (HCC) cell lines (HepG2, SNU398, SNU449 & SNU475), gastrointestinal cancer (GI) cell lines (Caco2 & HCT116), and normal skin fibroblast cell line (HS27) by RT-PCR (Fig. 2BI). The gene discussed is PRDM16; the disease is hepatocellular carcinoma.