CD8+ T cells participate in the endotheliopathy that is a hallmark of experimental cerebral malaria51,52 suggesting that CD8+ T cell-mediated induction of BBB leakage may be a general mechanism also occurring in other neuro-infectious (e.g., viral, toxoplasmosis)53,54 or putative autoimmune neuro-inflammatory diseases (e.g., Rasmussen encephalitis55). Here, CD8A is linked to toxoplasmosis.