Somewhat counterintuitively, our data show that detrimental synergy between IAV and Spn11,13,26,29,36,42 is reduced in the context of experimental allergic asthma where IAV + Spn co-infection in allergic mice resulted in a dramatically altered inflammatory landscape correlating with less overall lung inflammation and damage, reduced morbidity and enhanced bacterial clearance. The gene discussed is SPN; the disease is coinfection.