Through these findings, we have not only further supported that fact that neurotrophic factors such as BDNF may play a critical role in treatment of neurodegenerative disease, such as PD, but also further bolstered FUS-enhanced IN delivery as a potential non-invasive and effective drug delivery route to the CNS that may be clinically impactful. The gene discussed is BDNF; the disease is neurodegenerative disease.