IL6 and cancer: In patients and especially responders, in the Inflammatory Response (genes related to cytokines, growth factors, cell differentiation markers and transcription factors)36, IL6-JAK-STAT3-Signalling (aberrantly hyperactivated in patients with cancer and chronic inflammatory conditions)59, and TNFα Signalling via NFKβ (cell proliferation, differentiation, apoptosis, neuroinflammation mediated cell death) gene sets, strong upregulation was observed at T2.