GCLC and lung carcinoma: Specifically, the authors showed that endogenous KrasG12D, via the Raf-Mek-Erk-Jun pathway, transcriptionally activates Nrf2 and by extension Nrf2 target genes (Hmox1, Nqo1, Gclc, and Ggt1) in cells, genetically engineered mouse models (GEMMs) of pancreatic and lung cancer, and in human pancreatic cancer9 (Fig. 3).