The second highest degree small molecule node (degree=46) was emetine, an anti-malaria drug that was recently found to have broad anticancer activity in many types of malignancies including breast, colon, prostate, skin, and lymphoid tumors by inhibiting NF-κB signaling or regulating the RNA splicing of members of the Bcl-2 family [18, 19]. The gene discussed is BCL2; the disease is malaria.