Using a general cell stress reporter gene (hsp70:DsRed), McGown et al. (2013) demonstrated that mutant sod1 G93R zebrafish embryos had elevated stress in the spinal cord, which did not occur in transgenic zebrafish expressing wild-type (WT) sod1. Interestingly, these cells were identified as interneurons, mostly glycinergic interneurons, suggesting that this cell type might be particularly susceptible in disease progression at pre-symptomatic stages of ALS. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.