This fusion protein (264scTCR/IgG1) was able to bind to an unmutated peptide derived from human p53 (aa 264–272) presented in the context of HLA-A2.1 and stimulate potent antitumor effects in a model of experimental non-small cell lung carcinoma (NSCLC) metastasis in nude mice through ADCC. This evidence concerns the gene TP53 and non-small cell lung carcinoma.