This GWAS, with 1110 MO patients and 10,852 matched controls in Han-Chinese population, established that the top 6 SNPs (rs8050136, rs9939609, rs1421085, rs9941349, rs1121980, and rs9937354) were all located in the most replicable obesity gene: the FTO. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.