In order to assess the prognostic value of clinicopathological characteristics through the entire population of breast cancer patients, we constructed a Cox proportional hazards regression model to assess the hazards ratio of all parameters (age, tumor size, grade, ER status, PR status, HER-2 expression, lymph node metastases, Ki67 index, FOXP3 expression, and CCL20 expression) on breast-cancer-specific survival (Table 4). This evidence concerns the gene ESR1 and breast carcinoma.