Chemokines are small (8–14 kDa) secreted proteins that play key roles in recruiting and modulating the activity of inflammatory cells by interacting with their corresponding receptors.[25] Chemokine ligand 20 (CCL20), the ligand for CCR6, is secreted by tumor and stromal cells where they recruit macrophages, and leukocytes such as TILs to the tumor location.[26] Studies have shown CCL20 and CCR6 to be significantly upregulated in several solid tumors and closely associated with poor prognosis.[27–30]. This evidence concerns the gene CCL20 and neoplasm.