To overcome these limitations, a simple assessment method for liver functional reserve, called albumin-bilirubin (ALBI) grade, which is based on 2 objective parameters (serum albumin level and total bilirubin level), has been recently proposed.[5] The predictability of ALBI grade has been confirmed for patients with LC with or without HCC irrespective of liver disease etiologies.[6–12] Predicting clinical outcomes in patients with LC is challenging and is likely best accomplished with a combination of objective parameters in addition to the clinical course of LC. The gene discussed is ALB; the disease is hepatocellular carcinoma.