Somatic activating mutations of the G-protein alpha stimulatory subunit (Gsα subunit) encoded by the GNAS gene (GNAS) have been reported in up to 70% of pancreatic intraductal papillary mucinous neoplasms (IPMN),[4–7] that is a precursor of pancreatic adenocarcinoma. This evidence concerns the gene GNAS and pancreatic adenocarcinoma.