In a pre-clinical study, female fertility was affected by treatment with pazopanib, likely due to the suppressive effect of this drug on the endometriotic tissue expressions of VEGF and CD117.[21] A decreased number of corpora lutea along with an increased number of ovarian cyst and ovarian atrophy were observed in rats, even if without significant changes in the ovarian follicle number and ovarian reserve.[22]. The gene discussed is VEGFA; the disease is Ovarian cyst.