HMGA2 and leiomyoma: Approximately 30%–40% of fibroids have been reported as having karyotypic abnormalities, with the most commonly reported being translocations at chromosome regions of 12q15 and 6q21, leading to overexpression of the high mobility group AT-hook genes, HMGA2 and HMGA1, respectively (Nilbert et al., 1990; Sandberg, 2005).