CD8A and primary biliary cholangitis: Emperipolesis is one of cell‐in‐cell structures that have been observed in chronic viral hepatitis.5 Recently, a study on auto‐immune hepatitis showed emperipolesis to be predominantly mediated by CD8+ T cells, which appeared to induce apoptosis of hepatocytes and thus revealing another potential mechanism of autoimmune hepatocyte injury.6 In our previous study, we had shown that emperipolesis was frequently seen in PBC, while BEC was predominantly host cells.7 However, it remains unknown whether emperipolesis is involved in BEC injury.