Concomitantly, epithelial markers such as E‐cadherin are down‐regulated, whereas mesenchymal markers including Vimentin, collagen I and β‐catenin are up‐regulated.3 In 2019, a study provided evidence for the positive effects of SLC34A2 on EMT phenotype in glioma cell lines via the EGFR/PI3K/AKT signalling.4 However, the molecular mechanisms that act upstream of these factors in various physiological and pathologic contexts in pancreatic cancer are not well characterized. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.