For example, calreticulin increased β‐catenin protein expression to promote EMT via Integrin/EGFR‐ERK/MAPK signalling,24 and EGF‐induced nuclear translocation of SHCBP1 directly increased acetylation of β‐catenin to enhanced NSCLC cellular stemness,25 which is suggested that EGFR signalling can drive β‐catenin activation via various routes. This evidence concerns the gene SHCBP1 and non-small cell lung carcinoma.