Especially in lung cancer cells, PRMT5 was proved to promote cell proliferation through direct interaction with Akt and regulation of Akt activity.21 More recently, PRMT5 was demonstrated that lead to FBW7 expression to promote tumorigenesis in pancreatic cancer.14 In this study, we find that PRMT5 promotes cell proliferation, colony formation, migration and invasion in pancreatic cancer cells, and promotes tumorigenesis. This evidence concerns the gene FBXW7 and familial pancreatic carcinoma.