In our analysis of differentially methylated gene regions, DnaJ heat shock protein family (Hsp40) member A4 (DNAJA4) and Transferrin receptor 2 (TFR2) emerged as two interesting genes that have been previously reported in the literature to be associated with tissue growth and adipocytes, respectively.[34, 35] DNAJA4 encodes for a heat shock protein and has been reported to play a role in fetal growth as well as growth of sarcomas.[36, 37] We report that DNAJA4 promoter hypermethylation across 14 CpG sites was negatively associated with neonatal leptin levels, a measure of adiposity. The gene discussed is LEP; the disease is sarcoma.