In this cohort [46] and others,[47] leptin has been highly correlated with measures of newborn fat and higher levels may impair normal satiety signaling, energy expenditures, and promote the development of insulin resistance.[48] Therefore, the reported associations are notable findings that may reflect subtle, early life changes in a newborn’s metabolic state that may have long term impact on metabolic health. This evidence concerns the gene LEP and Insulin resistance.