TGFB1 and neoplasm: Thus, we performed signature validation contrasting the TN derived from the HCC6 dataset with reported HCC-related signatures: progenitor tumor cell origin (CSC_Yamashita, EPCAM_Yamashita, CK19_Andersen [15], S2_Hoshida [16] and C2_Cario [17]), cellular proliferation [18], vascular invasion [19], TGF-beta_Coulouarn [20], MET_Kaposi-Novak [21], G3_Boyault [22], S1_Hoshida (TGFβ-WNT) [16]), Recurrence_Woo [23], OS_Kim [24], Interferon_Chiang [18], and G5/6_Boyault (CTTNB1_WNT activation) [22].