SOD1 and amyotrophic lateral sclerosis: ALS: early muscle symptoms-weakness; wastingMuscle specific expression of SOD1 → MN degeneration (die-back hypothesis)Satellite cells: loss of regenerative capacityNF-κB implicationsMitochondrial dysfunction, oxidative/ER stress and autophagy defects = proposed ALS mechanismsFGFBP1 maintains NMJ in an ALS model