In addition, while the high expression of PECAM1/CD31 is related to the better prognosis of patients with kidney renal clear cell carcinoma, and skin cutaneous melanoma, the high expression of PECAM1/CD31 is related to the poor prognosis of patients with brain low grade glioma and uveal melanoma(Supplementary Figure 3). Here, PECAM1 is linked to cutaneous melanoma.