The most significant 10 hub genes were selected, and comprised VEGFA, FN1, ITGB2, ICAM1, CXCR4, PECAM1/CD31, TYROBP, CCND1, EGF, and CAV1. To screen for early diagnosis of renal cancer, we selected two genes that were elevated in the early stages of renal cell carcinoma: CCND1 and PECAM1/CD31. This evidence concerns the gene PECAM1 and hereditary clear cell renal cell carcinoma.