IFI16 and periodontal disorder: It is still not clear how many sensors are capable of forming inflammasomes, with strong literature support for over 10 different inflammasomes, including NLRP1, NLRP3, NLRP6, NLRP12, pyrin, NAIP/NLRC4, RIG‐I AIM2, IFI16, NLRC3, NLP6, recently reviewed elsewhere.3, 4, 5 Here we will focus on discussing the clinical and preclinical data supporting a potential role of NRRP1, NLRP3, pyrin, AIM2 and IFI16 in the context of periodontal disease pathogenesis.