Nuclear IFI16 binds to episomal viral DNA genomes and induces an inflammasome, specifically in response to Listeria monocytogens, herpesvirus and lentivirus infections.31, 32, 33 Structurally, IFI16 has two HIN200 domains, HINa and HINb, which are connected via a linker region. This evidence concerns the gene IFI16 and lentivirus infection.