Evidence also suggests that genetic variants in the NLRP3 gene are associated with increased risk for developing autoinflammatory Crohn's disease.85 A predicted regulatory region on chromosome 1q44 downstream of NLRP3 (rs10733113) was strongly associated with the risk of Crohn's disease (odds ratio = 1.78, confidence interval = 1.47‐2.16) and was consistently replicated in four sample sets from individuals with European descent.85 No study so far has reported genetic defects or variants in NLRP3 correlated with periodontal disease. This evidence concerns the gene NLRP3 and Crohn disease.