Current data report differences in tissue expression based on periodontal disease status, limited tissue characterization and correlation of specific gene variants with periodontitis.106, 107 In human gingival tissues, AIM2 levels were approximately two‐fold higher in the lamina propria and epithelium of chronic periodontitis compared with healthy controls and aggressive periodontitis.68 In that study, AIM2 was mainly expressed in epithelial cells. Here, AIM2 is linked to chronic periodontitis.