Only one clinical study so far has evaluated NLRP1 in the context of periodontal disease.68 NLRP1 was shown to be expressed at very low levels in the gingival tissues of healthy, chronic and aggressive periodontitis, with expression more frequently observed in the epithelium and connective tissue of individuals with aggressive periodontitis (n = 65).68 The data indicate that NLRP1 function is still not well defined in periodontal disease. The gene discussed is NLRP1; the disease is periodontitis.