IFI16 and periodontitis: Using these biologically informed, complex periodontal traits, we reported evidence of a genome‐wide association for 12 novel loci, specifically: periodontal complex trait‐1: CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, and RBMS3; periodontal complex trait‐3: C1QTNF7 and TSNARE; periodontal complex trait‐4: HPVC1; and periodontal complex trait‐5: SLC15A4, PKP2, and SNRPN. Some additional follow‐up evidence on the role of IFI16/AIM2 variants in periodontitis and their association with inflammatory and microbiologic parameters has since been reported by Marchesan et al.98