Their studies showed that DISC1 inhibition altered mitochondrial dynamics by regulating Drp1 (Gao et al., 2016), and that Drp1 activation was associated with a poor prognosis of glioblastoma (Xie et al., 2015), indicating that mitochondrial dynamics acted as a regulatory switch for the differentiation of glioma stem cells and could be a new therapeutic target. The gene discussed is DISC1; the disease is glioblastoma.