These results are in agreement with several studies that indicated significant increases in levels of: (i) miR-21 and miR-210 in serum samples from patients with peripheral arterial disease, specifically atherosclerosis obliterans (37); (ii) miR-34a and miR-146 in serum obtained from patients with newly diagnosed type II diabetes (38); (iii) miR-221 and miR-222, that indirectly repress endothelial nitric oxide synthase required for EPC functions, and (iv) miR-92a in patients with CAD (39). Here, NOS3 is linked to type 2 diabetes mellitus.