SLC5A2 and chronic kidney disease: The Dapa-CKD clinical trial (ClinicalTrials.gov Identifier: NCT03036150) is testing the effects of the SGLT-2 inhibitor dapagliflozin on kidney endpoints and CV mortality in patients with CKD with and without type 2 diabetes vs. placebo, whereas the EMPA-KIDNEY trial is exploring empagliflozin vs. placebo in patients with CKD in order to answer the question whether SGLT-2 inhibitors are effective in a wide range of patients with CKD, such as patients with albuminuria or with reduced eGFR regardless of albuminuria levels (Herrington et al., 2018).