Beyond the mDA system, Nurr1 expression has previously been reported in several additional brain areas (Zetterström et al., 1996a, b) including the cortex and hippocampus where its expression in glutamatergic neurons was recently implicated in cognitive functions of putative relevance to Alzheimer’s disease (Moon et al., 2019). Here, NR4A2 is linked to early-onset autosomal dominant Alzheimer disease.