Similarly, disease in Pstpip2cmo mice, which have a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene that results in debilitating inflammatory arthritis similar to that of patients with chronic multifocal osteomyelitis (cmo), is rescued when caspase-8 is inactivated in combination with either caspase-1 or the NLRP3 inflammasome (Ferguson et al., 2006; Grosse et al., 2006; Lukens et al., 2014; Gurung et al., 2016). This evidence concerns the gene CASP8 and chronic recurrent multifocal osteomyelitis.