CD274 and malignant glioma: Bioinformatics analysis of DEGs clearly pointed out that increased PD-L1 in glioma was closely associated with glioma malignancy (Figure 2A), as well as distinct signaling pathways in invasive malignant glioma, such as cell migration, PI3K/Akt and actin organization (Figures 2B–D and Figures S1, S3).