AFP and neoplasm: Previous studies have suggested that clinicopathological variables, including the presence of microvascular invasion (MVI), worse histological differentiation, microsatellite nodules, alpha-fetoprotein (AFP) level, and tumor size, were significant predictors for ER patients with eHCC after curative resection, but controversy exists as to which of these are more important, and some of these predictors can only be evaluated with postoperative pathological examination (5–7).