NCOR1 and hepatocellular carcinoma: In HCC, the convergence appears to occur sequentially, first, the loss of NCoR function due to UPS mediated misfolding of NCoR may cause the de-repression of putative NCoR target genes, possibly a lysomosal protease involved in ALP pathway, eventually leading to the degradation of misfolded NCoR protein through autophagy (Figure 9).