Therefore, depending on the cell type involved, the tumor cell specific degradation of misfolded NCoR may promote uncontrolled growth and transformation by ectopic reactivation of cellular stemness in relatively matured myeloid cells of monocytic AML (21) while it could activate pro-survival oncogenic signaling such as UPR and autophagy in nutrient depleted solid tumor microenvironment of NSCLC (22). This evidence concerns the gene NCOR1 and neoplasm.