The exact role of HBX in the ubiquitination of misfolded NCoR protein in HBX positive HCC cells remains unclear but based on our previous findings in promyelocytic AML where PML-RARα acted as an E3 ligase for the misfolded NCoR protein, a role of HBX as E3 ligase for misfolded NCoR in HBX positive HCC cells can't be rule out (16). The gene discussed is NCOR1; the disease is hepatocellular carcinoma.