The findings reported in this manuscript are consistent with those finding and suggest that HBX can also create a PML-RARα or MLL1-AF9 like effect on the conformation of NCoR protein through aberrant post-translational modification and transform the liver cells through similar oncogenic gain of function mechanism as observed in promyelocytic and monocytic AML. Here, KMT2A is linked to acute myeloid leukemia.