Similarly, as discussed by Stine Falsig Pedersen (University of Copenhagen, Denmark) in luminal breast carcinoma cells, targeting the Na+/H+ exchanger NHE1 and the Na+/HCO3- cotransporter NBCn1 delayed cell cycle progression in different ways, including the expression and phosphorylation of cell cycle regulatory proteins, with NHE1 mainly involved in the S phase and NBC1 in the G2/M phase. Here, SLC9A1 is linked to breast carcinoma.