Zeng et al. (46) analyzed the roles of MMR and p53 signaling in activation of autophagy and apoptosis using MLH1–/MLH1+ colorectal cancer cells (HCT116) as well as MSH2–/MSH2+ endometrial cancer cells (HEC59) after exposure to 6-thioguanine (6-TG). Here, MSH2 is linked to colorectal cancer.