Fucus vesiculosus (brown seaweed) extracts (FVE) appears to have display anti-cancer effects in estrogen receptor (ER)-dependent and -independent way in HEC-1-B and RL95-2 endometrial cancer cell lines by a competitive inhibition of estradiol (E2) binding to the estrogen receptor (100, 101). The gene discussed is ESR1; the disease is endometrial cancer.