PXR is highly expressed in pharmacologically relevant organs, such as the liver, intestinal tract, and kidney, as well as in many solid cancers, including CRC, with a local effect on the expression of several phase I/II enzymes, ATP-binding cassette (ABC), and solute carrier (SLC) membrane transporters (13–15, 28). The gene discussed is NR1I2; the disease is colorectal carcinoma.