First, most reported immune-related lncRNAs contribute to immunotherapy resistance through inducing immune evasion at different stages, including the loss or weakness of antigen presentation, upregulation of PD-L1 expression, attenuation of T-cell activities, and accumulation or immunosuppressive capacity increase of G-MDSCs and Tregs in tumor environment (Figure 1). The gene discussed is CD274; the disease is neoplasm.