KLK3 and posterior cortical atrophy: Ye et al. used CRISPR-Cas9 technology to delete GPRC6A in human PC3 cells and observed a diminishing reaction to L-Arg, osteocalcin, and testosterone stimulation of ERK, Akt, and mTOR phosphorylation with reduced cell proliferation and downregulation of OCN, PSA, MMP9, BMP3, RUNX2, and VEGF genes, which are involved in PCa progression (94).