A research was conducted in 2015 called The Stockholm (STHLM3) study to improve the performance of detecting PCa, wherein a combination of genetic tumor markers (232 SNPs), PSA concentration, plasma proteomic markers (MIC-1, MSMB, intact-PSA, free-PSA, and HK2), and standard clinical variables (prostate volume, family history, age, DRE, and previous biopsies) were tested in a cohort of Swedish men aged 50–69 years. Here, KLK3 is linked to posterior cortical atrophy.