(1) Tumor growth extending beyond the uterus;(2) High-grade nuclear and cellular polymorphism;(3) Extensive coagulative necrosis;(4) Destructive growth;(5) Deep myometrial infiltration;(6) Evidence of trophoblastic cells with clear cytoplasm;(7) > 5 mitotic figures per 10 HPF;(8) High proliferative activity (Ki-67 labeling index) of more than 50%. Here, MKI67 is linked to neoplasm.