Although in a limited number of cases, a significant difference was observed comparing E-cadherin negative cells in bone metastasis (N = 9; 14.77 ± 4.02) with those in soft tissues (N = 2; 26 ± 5.0) A positive correlation between E-cadherin negative cells (r = 0.8565, P = 0.0052) was found comparing only primary tumors with the respective paired bone metastasis. This evidence concerns the gene CDH1 and bone metastasis.