Transcriptional E-cadherin downregulation mediated by its promoter methylation is widely investigated in human PC (Graff et al., 1995; Yoshiura et al., 1995; Li et al., 2001; Mostafavi-Pour et al., 2015), and E-cadherin plasticity has been proposed during the metastatic progression in human PC (Bae et al., 2011). This evidence concerns the gene CDH1 and pachyonychia congenita.