MMP8 and obesity due to melanocortin 4 receptor deficiency: For example, MS4A1 is associated with the development of B-cells into plasma cells; CD37 may play a part in T-cell–B-cell interactions; CD5L participates in obesity-associated autoimmunity; MMP8, IRF5, and RHOF are related to innate immune pathways; MMP9 has a role in tumor-associated tissue remodeling; and TRAM1L1 is related to the well-known cancer-related NF-kB pathway.