MCPH1 and ocular melanoma: Kerschner et al. (2013) showed presence of inflammatory cells, changes in the mucosal epithelium, and ME fluid in Oxgr1 deficient mice. 4) Mcph1—the Mcph1-deficient mice had mild to moderate hearing loss (around 70% penetrance). Other defects of Mcph1-deficient mice included small skull sizes, increased micronuclei in red blood cells, increased B cells, and ocular abnormalities (Chen et al, 2013). 5) Lmna—Lmna mutant mice have profound early-onset hearing deficits and abnormal positioning of the Eustachian tube accompanied by OM (Zhang et al., 2012).