Segade et al. (2006) also reported nominal evidence of association to the SNP rs2134056 (p = 0.017) at FBXO11 in their cohort of 142 families from the US (with a mixed OM phenotype). The TGIF1 locus, found to be associated with risk of COME, has not been evaluated in any previous genetic association study. EVI1 and NISCH were not associated with OM (Sale et al., 2011). The gene discussed is NISCH; the disease is ocular melanoma.