Furthermore, when hypercholesterolemic rabbits were pretreated with the PPARG agonist rosiglitazone prior to ischemia/reperfusion or AMI, there was a significant decrease in the number of apoptotic cardiomyocytes and size of myocardial infarct observed (Liu et al., 2004). The gene discussed is PPARG; the disease is myocardial infarction.