In BC, the BRD4 histone acetylation reader is overexpressed and can upregulate C-MYC, which controls the expression of cell cycle progression genes, enhancing the recruitment of this factor to the EZH2 promoter and subsequently upregulating EZH2 expression, which has a significant relevance on tumor growth (Wu et al., 2016b). This evidence concerns the gene EZH2 and neoplasm.