EHMT2 and neuroblastoma: One of the first histone lysine methyltransferase inhibitors (HKMTi), specific against G9a (EHMT2), was BIX-01294 (Kubicek et al., 2007), which has been shown to inhibit cell proliferation in BC cell lines and induce apoptosis in neuroblastoma cells (Cui et al., 2015).