NOTCH1, part of the Notch signaling pathway, is involved in many processes related to cell fate specification, differentiation, proliferation, and survival, while its activation is related to many types of cancers (e.g. cervical, colon, head and neck, lung, renal, pancreatic, leukemia, and breast cancer) (Xiao et al., 2016). The gene discussed is NOTCH1; the disease is cancer.