AOC3 and obesity due to melanocortin 4 receptor deficiency: To cite one example, inhibition of the AOC3 (Amine Oxidase Copper Containing 3), playing important roles in adipogenesis and putatively targeted by miR166, could result in decreased fat deposition (Carpéné et al., 2007; Shen et al., 2012), hence addressing the big issues related to obesity and the many obesity-associated diseases.