RIOK3 and viral infectious disease: Particularly, the KPNA4 (Karyopherin Subunit Alpha 4) mediates the nuclear import of human cytomegalovirus UL84 (Lischka et al., 2003), PUM2 (Pumilio RNA Binding Family Member 2) plays a role in cytoplasmic sensing of viral infection (Narita et al., 2014), and RIOK3 (right open reading frame-RIO Kinase 3) is involved in regulation of type I interferon (IFN)-dependent immune response, with a critical role in the innate immune response against DNA and RNA viruses (Feng et al., 2014).