Nonetheless, there is growing evidence that the immunological environment of AD is not solely defined by Th2 cells and related cytokines (IL-4, IL-5, IL-10, IL-13, and IL-31) but also by cytokines linked to other Th cell responses such as IFN-γ (Th1), IL17, or IL-22 (Th17) and IL-33 (an alarmin) (8, 52–56). The gene discussed is IL17A; the disease is Alzheimer disease.