Indeed, despite the fact that complete knock-down of p53 was shown to induce radioresistance in HPV-driven HNSCC (37), Seltzsam et al. recently showed that radiation-induced p53 pathway activation after functional restoration of p53 by inhibition of proteasomal degradation does not sensitize HNSCC cells to irradiation (38). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.