While several studies focussed on the role of IL-33 in driving hepatic disease during schistosomiasis (27–29), hepatitis (30–32), or malaria (33), alone, very few investigations, if any at all, have been performed on the association of this cytokine with hepatic schistosomiasis infection and liver disease in a context of mixed infection. The gene discussed is IL33; the disease is schistosomiasis.