The level of Th1 cytokine responses in contact cases was generally lower than after-onset TB cases, and the difference was significant in IL-2 response against mHBHA and mMDP-1 (Figures 1C,D), and in TNF-α response against ESAT-6/CFP-10 and Acr (Figures 1A,B). This evidence concerns the gene TNF and tuberculosis.