In more details, the highest IFN-γ and TNF-α responses against ESAT-6/CFP-10 or Acr were observed in after-onset TB cases (active, on-treatment, and after-treatment cases) (Figures 1A,B), whereas the IFN-γ response against methylated (m) HBHA was less apparent (Figure 1C). The gene discussed is IFNG; the disease is tuberculosis.