A putative anti-tumor role of ILC2s has been proposed in a subcutaneous lymphoma mouse model, where sustained production of IL-33 induced the upregulation of CXCR2 on EL4 thymoma cells, the expansion of ILC2s and the concomitant production of CXCR2 ligands (CXCLs). The gene discussed is CXCR2; the disease is lymphoma.